Prior H1N1 influenza infection and susceptibility of cleveland family study participants during the H2N2 pandemic of 1957 : An experiment of nature. Commentary
Identifieur interne : 000123 ( 1957/Analysis ); précédent : 000122; suivant : 000124Prior H1N1 influenza infection and susceptibility of cleveland family study participants during the H2N2 pandemic of 1957 : An experiment of nature. Commentary
Auteurs : Edwin D. Kilbourne [États-Unis] ; Suzanne L. Epstein [États-Unis]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
During a pandemic, influenza vaccines that rely on neutralizing antibodies to protect against matched viruses might not be available early enough. Much broader (heterosubtypic) immune protection is seen in animals. Do humans also have cross-subtype immunity? To investigate this issue, archival records from the Cleveland Family Study, which was conducted before and during the 1957 pandemic (during which a shift from subtype H1N1 to H2N2 occurred), were analyzed. Only 5.6% of the adults who had had symptomatic influenza A in earlier study years developed influenza during the pandemic, despite living in households with participants who had influenza. In contrast, 55.2% of the children who had had symptomatic influenza A contracted it again. These findings suggest an impact of accumulated heterosubtypic immunity during a pandemic. Such immunity, as well as its implications for vaccination, should be further investigated.
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Pascal:06-0108310Le document en format XML
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Epstein</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Immunology and Developmental Biology, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologies Evaluation and Research, Food and Drug Administration</s1><s2>Rockville, Maryland</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0108310</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0108310 INIST</idno><idno type="RBID">Pascal:06-0108310</idno><idno type="wicri:Area/PascalFrancis/Corpus">000049</idno><idno type="wicri:Area/PascalFrancis/Curation">000025</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000040</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000040</idno><idno type="wicri:doubleKey">0022-1899:2006:Kilbourne E:prior:h:n</idno><idno type="wicri:Area/Main/Merge">001589</idno><idno type="wicri:Area/Main/Curation">001564</idno><idno type="wicri:Area/Main/Exploration">001564</idno><idno type="wicri:Area/1957/Extraction">000123</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Prior H1N1 influenza infection and susceptibility of cleveland family study participants during the H2N2 pandemic of 1957 : An experiment of nature. Commentary</title><author><name sortKey="Kilbourne, Edwin D" sort="Kilbourne, Edwin D" uniqKey="Kilbourne E" first="Edwin D." last="Kilbourne">Edwin D. Kilbourne</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, New York Medical College</s1><s2>Valhalla</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Valhalla</wicri:noRegion></affiliation></author><author><name sortKey="Epstein, Suzanne L" sort="Epstein, Suzanne L" uniqKey="Epstein S" first="Suzanne L." last="Epstein">Suzanne L. Epstein</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Immunology and Developmental Biology, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologies Evaluation and Research, Food and Drug Administration</s1><s2>Rockville, Maryland</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Infection</term><term>Influenza</term><term>Microbiology</term><term>Sensitivity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Sensibilité</term><term>Microbiologie</term><term>Infection</term><term>Grippe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During a pandemic, influenza vaccines that rely on neutralizing antibodies to protect against matched viruses might not be available early enough. Much broader (heterosubtypic) immune protection is seen in animals. Do humans also have cross-subtype immunity? To investigate this issue, archival records from the Cleveland Family Study, which was conducted before and during the 1957 pandemic (during which a shift from subtype H1N1 to H2N2 occurred), were analyzed. Only 5.6% of the adults who had had symptomatic influenza A in earlier study years developed influenza during the pandemic, despite living in households with participants who had influenza. In contrast, 55.2% of the children who had had symptomatic influenza A contracted it again. These findings suggest an impact of accumulated heterosubtypic immunity during a pandemic. Such immunity, as well as its implications for vaccination, should be further investigated.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><noRegion><name sortKey="Kilbourne, Edwin D" sort="Kilbourne, Edwin D" uniqKey="Kilbourne E" first="Edwin D." last="Kilbourne">Edwin D. Kilbourne</name></noRegion><name sortKey="Epstein, Suzanne L" sort="Epstein, Suzanne L" uniqKey="Epstein S" first="Suzanne L." last="Epstein">Suzanne L. Epstein</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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